Infants Model Calculator

This calculator aims to early identify biliary atresia in cholestatic infants whose age less than 100 days, gestational age more than 34 weeks or birth weight more than 2000g.

The Data you input will not be recorded and stored.

This is for your reference only, as peer review is ongoing

Calculator

Items

Value

Weight on admission
(Kg)

clay-colored stools

Abnormal gallbladder

GGT on admission
(u/L)

u/L

Total bilirubin on admission

Total bilirubin first repeated within 5-7 days following admission

Albumin on admission
(g/L)

g/L

Triangular cord sign

Result

P =

Risk =

Subjects

The algorithm was derived from 461 Chinese cholestatic infants (172 biliary atresia and 289 non-biliary atresia aged 2-97 days.
Cholestasis was defined as conjugated bilirubin >20% of the total bilirubin for total bilirubin of >85 mmol/L or >17 mmol/L for total bilirubin <85 mmol/L). Biliary atresia was confirmed by intraoperative cholangiography in combination with histological features of liver biopsies.

How to use

After enter measurements of weight on admission (Kg),
clay-colored stools (presence or absence),
abnormal gallbladder (presence or absence),
GGT on admission (U/L),
total bilirubin on admission (μmol/L or mg/dl),
total bilirubin first repeated within 5-7 days following admission (μmol/L or mg/dl),
albumin on admission (g/L),
triangular cord sign (presence or absence) ,
this calculator could estimate the probability of such infant having a biliary atresia, classify them into high-, intermediate-, and low-risk stratification and offer recommendations.

Note

Abnormal gallbladder (Ab-gallbladder) was defined as non-visualization of the gallbladder or gallbladder length ≤15 mm.
Triangular cord sign (TCS) was defined as the presence of an abnormal triangular or tubular echogenic area in the region of the porta hepatis.
ΔTBIL= first repeat total bilirubin within 5-7 days following admission- total bilirubin on admission.
Patients older than 100 days or gestational age <34 weeks or birth weight ≤2000g should be further evaluated by this calculator.

Formula

Ln (Odds of Biliary Atresia) = -3.5872 + 0.8644 * (Weight; kg) + 1.4572 * clay-colored stools + 1.8654 * Ab-gallbladder + 0.00317 * (GGT; u/L) + 0.0158 * (△TBIL; umol/L) - 0.0807 * (albumin; g/L) + 2.5456* TCS

Zhao et al. Web-based Calculator for Biliary Atresia Screening in Neonates and Infants with Cholestasis